Applied Science and Convergence Technology 2014; 23(1): 48-53
Published online January 30, 2014
Copyright © The Korean Vacuum Society.
Eun-Kyung Lima,b,c, Eunji Jangd, Seungjoo Haamb,d, and Yong-Min Huha,b*
aDepartment of Radiology, Yonsei University
bYUHS-KRIBB Medical Convergence Research Institute
cBioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology
dDepartment of Chemical and Biomolecular Engineering, Yonsei University
Correspondence to:Yong-Min Huh
We have formulated hexagonal-shaped gold nanoplates in a single-step for photothermal
therapy that gold ions to gold particles using pyrenyl dextran as reducible stabilizer and template.
They exhibit anisotropic structure with broad surface plasmon resonance (SPR) band into
near-infrared (NIR) spectrum enabling photothermal therapy. These gold nanoplates are also
confirmed biocompatibility and high uptake efficiency due to binding with dextran molecules
on the surface of gold nanoplates and cells. From in vitro phtothermal ablation study under
NIR laser, gold nanoplates have the potential to use as photothermal agents.
Keywords: Gold nanoparticle, Photothermal therapy, Hexagonal-shaped, Near-infrared, Absorption, Surface plasmon resonance