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Review Paper

Applied Science and Convergence Technology 2014; 23(2): 61-71

Published online March 30, 2014

Copyright © The Korean Vacuum Society.

Applications of Field-Effect Transistor (FET)-Type Biosensors

Jeho Parka, Hoang Hiep Nguyena,b, Abdela Woubitc, and Moonil Kima,b,c*

aBioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
bDepartment of Nanobiotechnology, University of Science and Technology (UST)
cDepartment of Pathobiology, College of Veterinary Medicine Nursing & Allied Health (CVMNAH),
Tuskegee University

Correspondence to:Moonil Kim

Received: March 17, 2014; Revised: March 24, 2014; Accepted: March 24, 2014

Abstract

A field-effect transistor (FET) is one of the most commonly used semiconductor devices.
Recently, increasing interest has been given to FET-based biosensors owing totheir outstanding
benefits, which are likely to include a greater signal-to-noise ratio (SNR), fast measurement
capabilities, and compact or portable instrumentation. Thus far, a number of FET-based
biosensors have been developed to study biomolecular interactions, which are the key drivers
of biological responses in in vitro or in vivo systems. In this review, the detection principles
and characteristics of FET devices are described. In addition, biological applications of
FET-type biosensors and the Debye length limitation are discussed.

Keywords: Field-effect transistor, Biosensor, MOSFET, ISFET, Nanowire FET

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