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Review Paper

Applied Science and Convergence Technology 2021; 30(5): 118-136

Published online September 30, 2021


Copyright © The Korean Vacuum Society.

Plasma Bioscience and Medicines

Eun Ha Choi , Young June Hong , and Nagendra Kumar Kaushik

Department of Electrical and Biological Physics, Plasma Bioscience Research Center & Applied Plasma Medicine Center, Kwangwoon University, Seoul 01897, Republic of Korea

Correspondence to:E-mail: ehchoi@kw.ac.kr

Received: May 18, 2021; Revised: June 9, 2021; Accepted: June 23, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


The nonthermal atmospheric biocompatible plasma, also called cold plasma, is the fourth state of matter, is a partially ionized gas consisting cocktail of gas’s molecules, free radicals, ions, electrons, and physical components such as photons, electric field and some heat. It has been successfully used in the biomedical, agricultural food safety, environment applications including industrial application for the processing of materials and etc. for not mentioned here. The recent discovery of its efficacy in sterilization of microorganisms has trigged a large quantity of research in the biomedical field. Here we review configurations and electrode layouts of typical plasma device for applications to biomedical such as cancer treatment and virus inactivation technology. Cocktail of reactive oxygen and nitrogen species (RONS) would be efficient and effective to several biomedical applications such as inactivation of drug-resistant bacteria, cancer treatment, inactivation of viruses, skin and dental applications. This detailed review provides an outline of typical plasma sources, their physical and chemical (RONS) characteristics based on their diagnostic methods, including cancer treatment strategies and inactivation of viruses. This review also emphasizing on strategises to control and inactivation of SARS-COV2 (COVID19) and rejuvenate lung cells. Plasma bioscience and medicine technologies will deliver a new model of therapeutic clinical systems along with sustainable application to environmental issues.

Keywords: Nonthermal atmospheric pressure biocompatible dielectric barrier discharged plasma, Cold plasma, Virus inactivation, Cancer treatment, Plasma bioscience and medicine

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