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Research Paper

Applied Science and Convergence Technology 2023; 32(1): 30-33

Published online January 30, 2023


Copyright © The Korean Vacuum Society.

High-Performance Device to Detect Interleukin-13 Based on Graphene Field-Effect Transistor

Chan Jae Shina , b , Sung Eun Seoa , c , Eunsu Ryua , d , and Oh Seok Kwona , b , e , f , ∗

aInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea
bDepartment of Biotechnology (Major), University of Science & Technology (UST), Daejeon 34141, Republic of Korea
cDepartment of Civil and Environmental Engineering, Yonsei University, Seoul 03722, Republic of Korea
dDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
eSKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 16419, Republic of Korea
fDepartment of Nano Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea

Correspondence to:oskwon79@kribb.re.kr

Received: October 6, 2022; Revised: December 7, 2022; Accepted: December 20, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Babies born prematurely may have difficulty with breathing and nutrition intake because many of their organs are less developed. In particular, childbirth before 32 weeks is known to fatally affect newborn survival and growth. Therefore, when signs of an impending premature birth are observed, delaying delivery through appropriate treatment is critical in the health and quality of life of mothers and newborns. In a previous study, above average concentrations of interleukin (IL) 13 were found to increase the likelihood of premature birth. Therefore, we fabricated anti IL-13 antibody-conjugated graphene field-effect transistor (Immuno field-effect transistor, ImmunoFET) to detect IL-13 protein, specifically. In detail, the response of the ImmunoFET to the target was highly sensitive and dose-dependent with the detection limit of 15 pg mL−1. Moreover, selectivity tests were performed to demonstrate the interference effects of IL-6 and IL-17, other cytokines associated with premature birth. Despite the existence of high concentrations of nontargets, our sensor was able to detect the target selectively. To the best of our knowledge, this platform is the first ImmunoFET to detect IL-13 based on a graphene field-effect transistor. Our newly fabricated device can be a great diagnostic tool for the preterm birth.

Keywords: Premature birth, Biosensor, Field-effect transistor, Nanotechnology

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